Received 23.04.2025

DOI: 10.35556/idr-2026-1(114)50-57

Study of the antimicrobial activity of a dental product with betulin
Sakanyan M.G. 1, ORCID: 0000-0001-8219-6358
Kosyreva T.F. 1, ORCID: 0000-0003-4333-5735
Samoilova M.V. 1, ORCID: 0000-0001-6771-919X
Zatevalov A.M.2, ORCID: 0000-0002-1460-4361
Zhilenkova O.G.3, ORCID: 0000-0003-3206-6648
Gudova N.V.3, ORCID: 0000-0002-9579-1102
¹ Peoples’ Friendship University of Russia named after Patrice Lumumba
117198, Russia, Moscow, Miklukho-Maklaya St., 4
² National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Health of Russian Federation
117997, Russia, Moscow, Akademika Oparina St., 4
³ G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology
125212, Russia, Moscow, Admiral Makarov St., 10

E-mail address: a_zatevalov@oparina4.ru

Summary
Dental products with antimicrobial activity play an important role in the prevention and treatment of oral diseases. One such remedy may be gel with betulin, the effectiveness of which has been studied against a number of microorganisms colonizing the oral cavity.
The aim of the study was to research the oral microbiome when using the anti-inflammatory drug with betulin for the treatment of periodontitis The study was conducted as a prospective comparative clinical trial involving patients with periodontitis and healthy volunteers. During the study, the species composition of microorganisms and the multidrug resistance of the isolated strains were determined. The main group included 36 patients (average age 28 years, range from 22 to 38 years) with diagnosed periodontitis. Inclusion criteria: clinical signs of periodontitis (bleeding gums, periodontal pocket more than 4 mm deep, inflammatory process). The control group consisted of 32 healthy volunteers (average age 28 years, range from 22 to 38 years) no signs of periodontal disease or systemic diseases.
The results showed that the use of drug with betulin resulted in a decrease in the prevalence and abundance of bacteria that cause inflammation and slow healing, in particular, Staphylococcus epidermidis, S. capitis, S. saprophyticus, Actinomyces oris and Rothia dentocariosa. There was no decrease in the number of representatives of the commensal flora – Streptococcus salivarius, Veillonella and Lactobacillus spp.
The effectiveness of the drug with betulin in the early stages of use against the anaerobic component of periodontal microflora has been confirmed. A conclusion was made on the need for development of prolonged maintenance therapy regimens.

Keywords: triterpenoids, cultural research, betadent.

For citation: Sakanyan M.G., Kosyreva T.F., Samoilova M.V., Zatevalov A.M., Zhilenkova O.G., Gudova N.V. Study of the antimicrobial activity of a dental product with betulin. Stomatology for All / Int. Dental Review. 2026; no. 1 (114): 50–57 (in Russian). doi: 10.35556/idr-2026-1(114)50-57

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