Received 09.01.2025

DOI: 10.35556/idr-2025-2(111)4-9
Microecology and oral immune defense during exercise as factors for local and systemic inflammation
Krivoshchapov M.V.1, ORCID: 0009-0009-3135-5748
Ilyushina A.V.4, ORCID: 0009-0006-5710-5147
Podporin M.S.2, ORCID: 0000-0001-6785-0016
Ponomareva A.G.2, ORCID: 0000-0002-2685-7235
Tsareva V.V.1, ORCID: 0000-0002-1287-7251
Statsenko E.A.3, ORCID: 0000-0002-7713-3333
1 Research Institute of Medicine and Dentistry, Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of the Russian Federation
127006, Russia, Moscow, Dolgorukovskaya St., 4A
2 Department of Microbiology, Virology, Immunology, Scientific and educational institute of fundamental medicine named after V.I. Pokrovsky, Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of the Russian Federation
127006, Russia, Moscow, Dolgorukovskaya St., 4A
3 Faculty of Medicine of the University of the United Arab Emirates
Abu Dhabi Emirate, Al Ain city, Tawam st., CMHS building, PO box 15551
4 Department of propaedeutics of conservative dentistry, Scientific and educational institute of stomatology named after A.I. Evdokimov, Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of the Russian Federation
127006, Russia, Moscow, Dolgorukovskaya St., 4A

E-mail address: nikola777@rambler.ru

Summary
Relevance of the research topic is related to the fact of increased young athletes morbidity, determined by hormonal changes of the pubescent period and a decrease in immunity with excessive or inadequate physical exertion.
Objective of the study is to substantiate the need to support the immunological reserves of young athletes using medicines based on the assessment of factors of innate immunity – lysozyme and lactoferrin.
Material and methods. A systematic review was conducted in foreign and domestic databases over the past ten years, including Medline www.ncbi.nlm.nih .gov; Russian scientific database elibrary https://www.elibrary.ru, Cochrane Library (The Cochrane Central Register of Controlled Trials (CENTRAL) www.thecochranelibrary.com.
Results. Аnalysis of the literature showed a decrease in immunological parameters, including factors of innate immunity lysozyme and lactofferin under high physical exertion in young athletes, which leads to the development of focal inflammatory processes in the entrance gate of infection. The consequence of these processes in the future is the possible development of somatic comorbid pathology.
Conclusion. The prevention of the spread of local infection in the oral cavity, nose and throat in young athletes is necessary with analogues of natural local immunity factors to maintain protection – lysozyme and transferrin.

Keywords: young athletes, innate immunity, lysozyme, lactoferrin, microelements.

For citation: Krivoshchapov M.V., Ilyushina A.V., Podporin M.S., Ponomareva A.G., Tsareva V.V., Statsenko E.A. Microecology and oral immune defense during exercise as factors for local and systemic inflammation. Stomatology for All / Int. Dental Review. 2025; no. 2 (111): 4-9 (in Russian). doi: 10.35556/idr-2025-2(111)4-9
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