Received 13/10/2023
DOI: 10.35556/idr-2024-1(106)44-51
Evaluation of the clinical efficacy of the composition based on superoxide dismutase and cluster silver in combination with an energy protector in therapy chronic generalized periodontitis
Popkov V.L.1, ORCID ID: 0000-0001-7362-0073,
Leontyev V.K.2, ORCID ID: 0000-0003-2296-8904,
Zadorozhny М.A.3, ORCID ID: 0000-0002-7528-6109,
Kheygetyan A.V.3, ORCID ID: 0000-0002-8222-4854,
Nektarevskaya I.B.3, ORCID ID: 0009-0009-6733-9977,
Galenko-Yaroshevsky P.A.1,4, ORCID ID: 0000-0001-6856-1777
1Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation
350063, Russia, Krasnodar, Mitrofana Sedina St., 4
2Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of The Ministry of Health of The Russian Federation
127006, Russia, Moscow, Dolgorukovskaya St. 4
3Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation
344022, Russia, Rostov-na-Donu, Per. Nakhichevanskiy, 29
4Research Institute of Pharmacology of Living Systems of Belgorod National Research University
308015, Russia, Belgorod, Pobeda St., 85

E-mail address: vict.popkoff2015@yandex.ru

Summary
The paper presents the results of studies on the effect of a drug composition in the form of gel, which includes two main components: a key enzyme of antioxidant defense of the body — superoxide dismutase (SOD) and a broad-spectrum antibacterial component in relation to aerobic, anaerobic, gram-positive and gram-negative microflora, including antibiotic-resistant — cluster silver and a metabolic drug on the therapeutic efficacy of the use of these drugs in the complex pharmacotherapy of patients with chronic generalized periodontitis (CHGP) moderate to severe severity.
Based on the data of clinical symptoms (pain, hyperemia, pathological mobility, etc.), indicators of the index assessment of the state of periodontal status (PI, PMA), the mathematized Schiller-Pisarev test and the index of interdental papillae bleeding (SBI) according to Muhlemann-Cowell observed the dynamics of changes in the state of the oral cavity and periodontal tissues in patients with CHGР.
It was established that the pharmacotherapy with the additional inclusion in the complex of drugs of traditional drug therapy of a gel, including SOD and cluster silver, as well as a drug of metabolic action, contributed to a more rapid relief of acute inflammatory processes in periodontal tissues, a decrease in the severity of destructive changes, a decrease in the manifestation of pathological symptoms, improving the reparative regeneration of periodontal support tissues and increasing the effectiveness of treatment of patients with CHGP.

Keywords: chronic generalized periodontitis, indices of periodontal condition, Schiller-Pisarev test.

For citation: Popkov V.L., Leontyev V.K., Zadorozhny М.A., Kheygetyan A.V., Nektarevskaya I.B., Galenko-Yaroshevsky P.A. Evaluation of the clinical efficacy of the composition based on superoxide dismutase and cluster silver in combination with an energy protector in therapy chronic generalized periodontitis. Stomatology for All / Int. Dental Review. 2024; no.1(106): 44—51 (in Russian). doi: 10.35556/idr-2024-1(106)44-51

References
1. Balmasova I.P., Tsarev V.N., Yanushevych O.O., Maev I.V., Mkrtumyan A.M., Arutyunov S.D. Microecology of periodontium. Relationship between local and systemic effects. Moscow, Practical Medicine. 2021; 258 p. (in Russian).
2. Grudyanov A.I. Periodontal Diseases: Educational and Methodological Guidance. 2022; 416 p. (in Russian).
3. Gulyaeva O.A., Bulyakov R.T., Gerasimova L.P., Chemikosova T.S. Modern methods in complex treatment of inflammatory periodontal diseases: monograph. 2016; 190 p. (in Russian).
4. Zorina O.A., Amkhadova M.A., Abaev Z.M., Khamukova A.A., Demidova A.A. Hypoxia-dependent transcriptional control of the activity of destructive periodontal changes of inflammatory and malignant genesis. Stomatology. 2020; no.3(99): 32—36 (in Russian). doi: 10.17116/stomat 20209903132
5. Leontyev V.K., Faustov L.A., Galenko-Yaroshevskiy P.A., Popkov V.L. Chronic generalized periodontitis: clinical and experimental pharmacotherapy with metabolic correctors. 2012; 403 p. (in Russian).
6. Leontyev V.K., Tseluyko K.V., Zadorozhniy A.V., Popkov V.L., Galenko-Yaroshevsky.Р.A. Effect of the combination of nanosilver and a new injectable form of rexode on the state of periodontal tissues in experimental periodontitis in rats. Stomatology for All / Int. Dental Review. 2020; no.2: 12—16 (in Russian). doi: 10.35556/IDR-2020-2(91)12-16
7. Clinical Pharmacology: Textbook (Edited by S.V. Okovitov, A.N. Kulikov). M.: GEOTAR-Media; 2022; 848 p. (in Russian).
8. Lukyanova L.D. Signaling mechanisms of hypoxia. Moscow: RAN; 2019; 215 p. (in Russian).
9. Lyubomirskiy G.B. Use of adhesive balm with magnetic polymers, hexetidine, citylpyridinium chloride and hyaluronic acid in the treatment of inflammatory periodontal diseases. Medical alphabet. 2022; no.2: 71—75 (in Russian). doi: 10.33667/2078-5631-2022-2-71-75
10. Meladze S.V., Kozlenko V.A. Pharmacotherapeutic efficacy of Soderm-Forte® gel and a new injection form of rexod® in complex treatment of experimental periodontitis. Sb. Abstracts of the 83rd Interregion. Scientific and Practical Conf. From the International. participation of students. of the Scientific Society named after Prof. N. Pyatnitskogo. 2022: 1220—1226 (in Russian).
11. Nozhkina N.N., Simonyan E.V., Sinitskiy A.I. Development of quality standards and standardization of dental medicinal film containing succinic acid and cetylpyridinium chloride. Postgraduate Bulletin of the Volga Region. 2020; no.1—2: 137—141 (in Russian). doi: 10.17816/2072-2354.2020.20.1.137-141
12. Opravin A.S., Galieva A.S., Davidovich N.V., Spiricheva E.P., Polivanaya E.A., Bazhukova T.A. Periodontal pathogenic microflora and antibiotic resistance in persons with chronic generalized periodontitis. Parodontologiya. 2023; no.1(28): 39—47 (in Russian). doi: 10.33925/1683-3759-2023-28-1-39-47
13. Popkov V.L., Leontyev V.K., Tseluyko K.V., Zadorozhniy A.V., Kheygetyan A.V., et al. Effect of a pharmacological composition with a gel based on superoxide dismutase and nanocluster silver on the indicators of blood microcirculation in the gums of rats under the conditions of experimental pathology. Stomatology for All / International Dental Review. 2022; no.3(100): 53—59 (in Russian). doi: 10.35556/IDR-2022-3(100)53-59
14. Ryzhova I.P., Pogosyan N.M., Gontarev S.N., Chuev V.V., Gontareva I.S., Chueva A.A. Analysis of modern approaches in the treatment of inflammatory diseases of the oral cavity (review). Clinical Dentistry. 2023; no.3(26): 14—19 (in Russian). doi: 10.37988/1811-153X_2023_3_14
15. Stepanov E.A., Kurashvili L.V., Mikulyak N.I., Moiseev Ya., Kinzirskiy A.S. Features of microcirculation in periodontium in various systemic diseases. News of Higher Educational Institutions. Volga region. Medical Sciences. 2021; no.2: 137—150 (in Russian). doi: 10.21685/ 2072-3032-2021-2-13
16. Uspenskaya O.A., Kondyurova E.V., Spiridonova S.A. Dynamics of markers of oral fluid lipid peroxidation in chronic periodontitis. Institute of Dentistry. 2021; no.2(91): 74—75 (in Russian).
17. Tseluyko K.V., Zadorozhniy A.V., Popkov V.L., Galenko-Yaroshevsky P.A. Effect of multi-targeted agent Soderm-Forte® on the course of inflammatory pathology in the tissues of the periodontal complex. 5th Russian Conf. by med. Chemistry with International. participation in MedChem-Russia 2021. 2021; 80 p. (in Russian).
18. Tsarev V.N., Yagodina E.A., Tsareva T.V., Nikolaeva E.N. Significance of viral-bacterial consortium in the emergence and development of chronic periodontitis. Parodontologiya. 2020; no.2(25): 84—89 (in Russian). doi: 10.33925/1683-3759-2020-25-2-84-88
19. Tsepov L.M., Nikolaev A.I., Nesterova M.M., Tsepova E.L., Tsepov A.L. Multiple chronic systemic diseases and periodontal pathology. Parodontologiya. 2019; no.2(24): 127—131 (in Russian). doi: 10.33925/1683-3759-2019-24-2-127-131
20. Tsinecker D.T., Modina T.N., Khusainov I.Kh., Tsinecker D.A., Gaffarova A.A., Shaidullin A.I., et al. Comorbidity of periodontitis and herpes in the post-COVID period. Clinical Dentistry. 2023; no.1(26): 98—104 (in Russian). doi: 10.37988/1811-153X_2023_1_98
21. Celik D., Kantarci A. Vascular changes and hypoxia in periodontal disease as a link to systemic complications. Pathogens. 2021; no.10(10): 1280. doi: 10.3390/pathogens10101280
22. Fernandez-Bravo S.E. Antioxidants in Dentistry: Oxidative Stress and Periodontal Diseases. In: Bravo-Diaz, C. (eds) Lipid Oxidation in Food and Biological Systems. Springer. 2022: 341—359. doi: 10.1007/978-3-030-87222-9_15
23. Galenko-Yaroshevsky P.A., Tseluiko K.V., Leontyev V.K., Zadorozhniy M.A., Popkov V.L., Zelenskaya A.V., et al. The effectiveness of Soderm®-forte gel and a new injectable dosage form of Rexod® in the complex treatment of experimental periodontitis in rats. Research Results in Pharmacology. 2022; no.1(8): 51—58. doi: 10.3897/rrpharmacology.8.79641
24. Novikov V.E., Levchenkova O.S., Ivantsova E.N., Vorobieva V.V. Mitochondrial dysfunctions and antihypoxants. Reviews on Clinical Pharmacology and Drug Therapy. 2019; no.4(17): 31—42. doi: 10.17816/RCF17431-42
25. Parma C. Paradontopathen. Leipzig. 1960; 250 p.
26. Russell A. A System of Classification and scoring for prevalence surveys of Periodontal Disease. Journal of Dental Research. 1956; no.35: 350—359. doi: 10.1177/220345560350030401
27. Saranraj P., Asokan N. Free Radical — A Sword with two Edges. Asian Journal of Research in Chemistry. 2021; no.2(14): 1—6.
28. Yadalam P.K., Kalaivani V., Fageeh H.I., Ibraheem W., Al-Ahmari M.M., Khan S.S., et al. Future drug targets in periodontal personalised medicine-a narrative review. Journal of Personalezed Medicine. 2022; no.3(12): 371 p. doi: 10.3390/jpm12030371