Received 07.07.2022
DOI: 10.35556/idr-2022-3(100)53-59
Influence of pharmacological composition with gel, containing superoxide dismutase and silver nanocluster monomers, and recombinant human superoxide dismutase on blood microcirculation in the gums of rats under experimental pathology

Popkov V.L.1, ORCID ID https://orсid.org/0000-0001-7362-0073
Tseluyko K.V.2, ORCID ID https://orсid.org/0000-0001-6856-1777
Leontyev V.K.3,ORCID ID https://orсid.org/0000-0003-2296-8904
Zadorozhny A.V.3, ORCID ID https://orсid.org/0000-9552-8542
Kheygetyan A.V.2, ORCID ID http://orсid.org/0000-0002-8222-4854
Zadorozhny M.A.2, ORCID ID https://orсid.org/0000-0002-7528-6109.
Galenko-Yaroshevsky P.A.1,4 ORCID ID http://orсid.org/0000-0001-6856-1777.
1 Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation
Russia, 350063, Krasnodar, St. Mitrofana Sedina, 4
2 Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation
Russia, 344022, Rostov-on-Don, Per. Nakhichevanskiy, 29.
3 Federal State Budgetary Educational Institution of Higher Education “A.I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russian Federation
Russia, 127473, Moscow, Delegatskaya St., 20, bld. 1
4 Research Institute of Pharmacology of Living Systems of Belgorod National Research University
Russia, 308015, Belgorod, Pobeda St., 85.

E-mail address: vict.popkoff2015@yandex.ru

Summary
It is shown that in experiments on narcotic male rats of the Wistar line using laser Doppler flometry (LDF) under conditions of induced (ligature) experimental periodontitis (EP), indicators of blood microcirculation in the gum mucosa in the lower incisors is reduced compared with intact periodontium. When using traditional drug therapy (TDT) in the conditions of EP in the selected localization, observed a significant promotion in blood microcirculation after a 12-day period of treatment. However, on the 74th day of the study, it decreases. The use of TDT in combination with gel, containing cluster silver in the form of micelle monomers and cluster monomers of the AgK+ type and superoxide dismutase, and a new injectable form, which is a recombinant human superoxide dismutase, under EP conditions in the selected field of study both after applying the pharmacological composition for twelve days, and on the 74th day of the experiment caused an increase in microcirculation to the original values.

Keywords: induced experimental periodontitis, indicators of blood microcirculation in the gum mucosa, Soderm-Forte® gel, a new injectable form of Rexode®.

For citation: Popkov V.L., Tseluyko K.V., Leontyev V.K., Zadorozhniy A.V., Kheygetyan A.V., Zadorozhniy M.A., Galenko-Yaroshevsky P.A. Influence of pharmacological composition with gel, containing superoxide dismutase and silver nanocluster monomers and recombinant human superoxide dismutase on blood microcirculation in the gums of rats under experimental pathology. Stomatology for All / Int. Dental Review. 2022, no.3(100): 53-59 (In Russian). doi: 10.35556/idr-2022-3(100)53-59

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