Received 30.11.2022
DOI: 10.35556/idr-2023-1(102)48-55
Pathophysiological and clinical aspects of comorbidity of coronavirus disease and chronic generalized periodontitis (literature review)
Sandler I.V., Amkhadova M.A.
Moscow Regional Research and Clinical Insitute (MONIKI)
Russia, 129110, Moscow, Shchepkina St, 61/2, bld. 1

E-mail address:

The purpose of the literature review was to conduct a general analysis of the literature data on the study of comorbidity between coronavirus disease and inflammatory periodontal diseases. Studies have found that periodontitis is significantly associated with a higher risk of complications from COVID-19, including intensive care unit hospitalization, the need for assisted ventilation and death, as well as increased blood levels of markers associated with worse COVID-19 outcome. 19, such as D-dimer, serum leukocyte level and CRP concentration. The article describes the mechanisms of penetration of the SARS-CoV-2 virus into the human body, the common links of pathogenesis between COVID-19 and periodontitis, the importance of oral hygiene for patients with COVID-19, and considers the clinical and general immunological aspects of inflammation in COVID-19 and periodontitis. Currently, most research is focused on whether the presence of periodontal disease affects the outcome of coronavirus disease. The possibility of cross-talk between SARS-CoV-2 and the oral microbiome, which may affect the subsequent course of periodontitis at the post-covid stage, presents the scientific interest.

Keywords: coronavirus disease, periodontitis, inflammation, comorbidity.

For citation: Sandler I.V., Amkhadova M.A. Pathophysiological and clinical aspects of comorbidity of coronavirus disease and chronic generalized periodontitis (literature review). Stomatology for All / Int. Dental Review. 2023, no.1(102): 48-55 (In Russian). doi: 10.35556/idr-2023-1(102)48-55

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