Received 15.06.2025

DOI: 10.35556/idr-2025-4(113)70-76
Evaluation of the condition of tissues of temporary teeth of children with hypophosphatasia using computed micro-tomography
Alekseeva I.A., ORCID: 0000-0002-9409-3046
Kiselnikova L.P., ORCID: 0000-0003-2095-9473
Petrovskaya V.V., ORCID: 0000-0001-8298-9913
Lezhnev D.A., ORCID: 0000-0002-7163-2553
Drobyshev A.Yu.,
Redko N.A., ORCID: 0000-0001-7807-9351
Kunizhev K.A., ORCID: 0009-0001-9077-6528
Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of the Russian Federation
127006, Russia, Moscow, Dolgorukovskaya St., 4

E-mail address: alexeeva.penza@yandex.ru

Summary
The aim of this study was to compare the morphometric data and mineral density of primary teeth in children with hypophosphatasia and healthy peers. The in vitro study design included a comparative analysis of scanned samples of primary teeth from pediatric patients with hypophosphatasia and somatically healthy children of the same age using computed microtomography (micro-CT). The analysis revealed that hypophosphatasia in children is associated with impaired structural formation of dental mineral tissues, manifested by changes in thickness and impaired tissue mineralization processes. Reduced levels of dentin and cementum mineralization were detected, significantly low in the cervical zone (at the enamel-cement junction), and the presence of erosion (destructive changes) along the entire contour of the roots of primary teeth, which may be associated with a deficiency of tissue-specific alkaline phosphatase, which is critical for tissue mineralization. The noted features of the morphology and mineral profiles of dental tissues may be an important criterion for assessing genetic disorders in the formation of mineral structures in a rare hereditary disease – hypophosphatasia.

Keywords: hypophosphatasia, children, computed microtomography, samples of primary teeth.

For citation: Alekseeva I.A., Kiselnikova L.P., Petrovskaya V.V., Lezhnev D.A., Drobyshev A.Yu., Redko N.A., Kunizhev K.A. Evaluation of the condition of tissues of temporary teeth of children with hypophosphatasia using computed microtomography. Stomatology for All / Int. Dental Review. 2025; no. 4 (113): 70–76 (in Russian). doi: 10.35556/idr-2025-4(113)70-76

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