Received 06.06.2020
DOI: 10.35556/idr-2021-1(94)34-38
The role of NOD-like receptors of innate immune cells in the pathogenesis of chronic periodontitis. Literature review

Grudyanov A.I.1, http://orcid.org/0000-0003-3818-9307
Fomenko E.V.1, http://orcid.org/0000-0003-4747-8039
Kalyuzhin O.V.2, http://orcid.org/0000-0003-3628-2436
1 National Medical Research center of dentistry and maxillofacial surgery of the Ministry of Health of the Russian Federation, Moscow, Russia
Russia , 119021, Moscow, Timura Frunze st., 16.
2 Department of Clinical Immunology and Allergy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
Russia , 119048 , Moscow, Trubetskaya st., 8 , bld. 2

Summary
In the article, based on the data from literary sources, the features of the development of inflammatory periodontal diseases and immune reactions in periodontitis are considered. It is shown that the structure of innate human immunity is based on the cellular system for the rapid recognition of pathogenic microbes as foreign bodies and their destruction. Effective recognition of pathogens BY toll-and NOD-receptors of innate immunity causes the production of cytokines and chemokines, α-and β-defensins, has an antimicrobial effect and attracts a large number of cells of the immune system to the focus of attack of microorganisms. It is concluded that the study of the exact mechanism of action of NOD receptors and their interaction with other image-recognizing receptors will lead to the development of more effective and subtle methods of controlling the inflammatory response in periodontitis.

Keywords: periodontitis, innate immunity, NOD-like receptors.

For citation: Grudyanov A.I., Fomenko E.V., Kalyuzhin O.V. The role of NOD-like receptors of innate immune cells in the pathogenesis of chronic periodontitis. Literature review. Stomatology for All / Int. Dental Review. 2021, no.1(94): 34-38 (In Russian). doi: 10.35556/idr-2021-1(94)34-38

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