Received 01.02.2021
DOI: 10.35556/idr-2021-1(94)40-44
Antimicrobial chemotherapy algorithm for periodontitis
Ushakov R.V.1, ORCID: SPIN-код: 3053-3900, AuthorID: 701309
Tsarev V.N.2, ORCID: AuthorID: 638394 SPIN-код: 8180-4941
Nuruev N.N.1, ORCID:
1 Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation
Russia, 123242, Moscow, Barrikadnaya St., 2/1 2 Federal State Budgetary Educational Institution of
Higher Education “A.I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russian Federation
Russia, 127473, Moscow, Delegatskaya St., 20, bld. 1

E-mail address:

In the article is justified the choice of drugs and the need to conduct antimicrobial chemotherapy for periodontitis. On the basis of literature data and their own studies, the authors proposed an algorithm for antimicrobial chemotherapy of periodontitis, prevention of local andgeneral complications during paradontological interventions in accordance with the AWaRe classification (WHO). Antibiotics are divided into drugs of the first and second empirical choices depending on the form of periodontitis.
Keywords: periodontitis, biofilm, systemic antibacterial chemotherapy.
For citation: Ushakov R.V., Tsarev V.N., Nuruev N.N. Antimicrobial chemotherapy algorithm for periodontitis. Stomatology for All / Int. Dental Review. 2021, no.1(94): 40-44 (In Russian). doi: 10.35556/idr-2021-1(94)40-44

1. Orekhova L.Yu., Loboda E.S., Kosova E.V., Vashneva V.Yu., Petrov A.A. Actual antibiotic therapy in periodontology. Periodontology. 2020, 25(3): 217—223. doi:
10.33925/1683-3759-2020-25-3-217-223 (In Russian).
2. Ushakov R.V., Tsarev V.N. Use antibiotics in dentistry. Moscow, 2018, 185 p. (In Russian).
3. Ushakov R.V., Tsarev V.N. Antimicrobial therapy in dentistry. Principles and algorithms. Moscow: Practical medicine, 2019, 240 p. (In Russian).
4. Tsarev V.N., Ippolitov E.V., Nikolaeva E.N. Distribution of genetic markers of antibiotic resistance in biofilm-forming strains of obligate and facultative anaerobes. Journal of Microbiology, Epidemiology and Immunobiology. Moscow. 2017, №2: 74—80. (In Russian).
5. Tsarev V.N., Ushakov R.V., Ippolitov E.V., Podporin M.S., Nuruev N.N. Experimental study of the antimicrobial and antibiofilm activity of the combination of ciprofloxacin and tinidazole in vitro. Parodontologija. 2019, 24(4): 285— 292. doi: 10.33925/1683-3759-2019-24-4-285-292 (In Russian).
6. Tsarev V.N., Ushakov R.V., Pozharskaya V.O., Ippolitov E.V. Principles of Antibacterial and Immunomodulatory Therapy in Dentistry. In: Microbiology, virology and oral immunology (Under ed. Prof. V.N. Tsareva). Moscow: GEOTAR-Media, 2013: 273—335 (In Russian).
7. Assem N.Z., Alves M.L.F., Lopes A.B., Gualberto E.C. Junior, Garcia V.G., Theodoro L.H. Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis. Braz Oral Res. 2017, Jul 3, 31: e67. doi: 10.1590/1807-3107BOR-2017.vol31.0067.
8. Keestra J.A., Grosjean I., Coucke W., et al. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res. 2015, 50(3): 294— 314. doi:10.1111/jre. 12221.
9. Ramich T., Schacher B., Scharf S., et al. Subgingival plaque sampling after combined mechanical and antibiotic-nonsurgical periodontal therapy. Clin Oral Investig. 2015, 19(1): 27—34. doi: 10.1007/s00784-014-1208-3.
10. Slots J. Research, Science and Therapy Committee. Systemic antibiotics in periodontics. J Periodontol. 2004, Nov, 75(11): 1553—1565. doi: 10.1902/jop. 2004.75.11.1553.