DOI: 10.35556/idr-2020-2(91)50-55

Impact of medical titanium implant surface on the efficiency of fibrointegration

Davydova T.R., Shaikhaliev А.I., Usatov D.A., Gasanov G.A., Korgoloev R.S.
I.M. Sechenov First Moscow State Medical University, Russia, 119048, Moscow, Trubetskaya St., 8, bld. 2

E-mail address:

The aim of this study was to study the effect of surface branching of titanium endoprostheses on the efficiency of fibrointegration. The object of the study was samples of titanium alloy Ti6Al4V in the form of disks with a diameter of 5 mm and a thickness of 1 mm with various surface treatments:
1) samples with a rough surface after sandblasting;
2) samples with a rough surface after sandblasting with a bioactive coating of titanium dioxide TiO2 with anatase structure.
The study of surface roughness was carried out by profilometry.
Evaluation of the spreading and proliferation of cells on the surface of test samples, as well as evaluation of the effectiveness of fibrointegration was carried out according to standard methods using scanning electron microscopy. During the experiments, mesinchymal stem cells were sown on test samples and the test samples were introduced into the soft tissues of experimental animals.
Based on the results obtained, it was concluded that the technology of forming rough surfaces by sandblasting does not provide high uniformity and reproducibility in the nanometer range and, apparently, another method for obtaining a rough surface should be chosen. The application of a bioactive coating of titanium dioxide TiO2 with the anatase structure to the surface of titanium endoprostheses increases the efficiency of fibrointegration, however, primarily the fibrointegration of titanium endoprostheses depends on their surface roughness, which determines the concentration of cell structures, the intensity of their adhesion and the ability to fibrointegrative process.

Keywords: titanium implant, surface morphology, anatase, atomic layer deposition, surface profiling, scanning electron microscopy, fibrointegration, mesenchymal stem cells, in vitro implant testing.

For citation: Davydova T.R., Shaikhaliev А.I., Usatov D.A., Gasanov G.A., Korgoloev R.S. Impact of medical titanium implant surface on the efficiency of fibrointegration. Stomatology for All / Int. Dental Review. 2020; No.2(91); 50-55 (In Russian). doi: 10.35556/idr-2020-2(91)50-55


1. Alyokhin A.P., Markeev А.М., Tetyukhin D.V., et al. Influence of the physicochemical properties of the surface of titanium implants and methods for their modification on the osseointegration indicators (Part I. Main indicators of osseointegration depending on the properties of the implant surface). Clinical Dentistry. 2009, no.3: 81—83 (in Russian).
2. Alyokhin A.P., Boleiko G.M., Gudkova S.A., Markeev А.М., Sigarev A.A., Toknova V.F., Kirilenko A.G., Lapshin R.V., Kozlov E.N., Tetyukhin D.V. Synthesis of biocompatible surfaces using nanotechnology. Russian Nanotechnologies, 2010, Vol.5, no.9: 10, 128—136 (In Russian).
3. Liu X., Chu P.K., Ding C. Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mater. Sci. Eng. A. 2004. V.47: 49. doi:10.1016/j.mser.2004.11.001
4. Titanium in Medicine. Materials Science, Surface Science, Engineering, Biological Responses and Medical Applications (Eds. Brunnette D.M. et al.), Berlin, Germany; Springer. 2001.
5. Steinemann S.G. Titanium — the material of choice? Periodontology. 1998, V.17: 7.
6. Heinrichs J., Jarmar T., Rooth al. Key Engineering Materials. 2008: 361—363, 689.
7. Shaikhaliev A.I., Polisan A.A,, Ivanov S.Yu., Kiselev D.A., Parkhomenko Yu.N., Malinkovich M.D., Cherkesov I.V., Temirov A.A., Molchanov S.A. Methods for Studying Materials and Structures in Electronics as Applied to the Development of Medicinal Endoprostheses of Titanium with Enhanced Fibroinegration Efficiency. Russian Microelectronics. 2018; December, 47(8): 575—582.
8. Shaihaliev A.I, Krasnov M.S., Il’ina A.P., Yamskova O.V., Rybakova E.Yu., Sventskaya N.V., Yamskova V.P., Yamskov I.A. Influence of Chemical Nature of Implant Materials on Regeneration Processes in Implant Site. Биофизика. 2016, V. 61, 4: 813—822.
9. Shaikhaliev А.I., Stretskiy G.М.,Krasnov М.S. et al. The effect of new compositions on the restoration of bone defects in rats in experiment 1. Fundamental Research. 2013, no.9(2): 271 (in Russian).