DOI: 10.35556/idr-2020-2(91)24-29

Clinical effectiveness of the composition of muramylpeptides from gram-negative bacteria in the treatment of severe chronic generalized periodontitis

Grudyanov A.I.1, Fomenko E.V.1, Kalyuzhin, O.V.2
1 National Medical Research center of dentistry and maxillofacial surgery of the Ministry of Health of the Russian Federation, Russia, 119021, Moscow, Timura Frunze St., 16
2 Department of Clinical Immunology and Allergy, I.M. Sechenov First Moscow State Medical University, Russia, 119048, Moscow, Trubetskaya St., 8, bld. 2

Summary
The effectiveness of the immunomodulator Polymuramil (PM) was determined in the treatment of 40 patients with severe chronic generalized periodontitis based on the dynamics of the values of periodontal indices and the content of periodontal pathogens in the periodontal pockets. Patients of the main group (20 people) were treated with professional hygiene (PGO) in combination with daily intramuscular PM for 5 days at a dose of 200 mcg. Patients of the control group (20 people) were performed only PGO. The effectiveness of treatment was evaluated based on the dynamics of the clinical indices of Muehlemann and PMA and the presence or absence of major periodontal pathogens in the periodontal pockets. Results: in patients of the main group, the phenomena of periodontal inflammation and the main periodontal pathogens were eliminated in a shorter time and to a greater extent in comparison with patients of the control group.Keywords: periodontitis, periodontal indices, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, immunotherapy, muramyl peptides, Polymuramil.

Keywords: periodontitis, periodontal indices, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, immunotherapy, muramyl peptides, Polymuramil.

For citation: Grudyanov A.I., Fomenko E.V., Kalyuzhin, O.V. Clinical effectiveness of the composition of muramylpeptides from gram-negative bacteria in the treatment of severe chronic generalized periodontitis. Stomatology for All / Int. Dental Review. 2020, no.2(91), 24-29 (In Russian). doi: 10.35556/idr-2020-2(91)24-29

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