DOI: 10.35556/idr-2020-2(91)60-63

Association of normal oral mucosa with DNA of the main types of oncogenic viruses
Kutukova S.I.1, 2, Chukhlovin A.B.1, Yaremenko A.I.1, Ivaskova Yu.V.1, 2, Razumova A.Ya.1, Ermakova T.S.2
1 Pavlov First Saint Petersburg State Medical University, 197022, Russia, Saint Petersburg, L’va Tolstogo St., 6-8
2 City Clinical Oncology Center, Saint-Petersburg, 198255, Russia, Saint-Petersburg, Prospekt Veteranov, 56

E-mail address: dr.s.kutukova@gmail.com

Summary
The aim of the study was to assess the prevalence of DNA viruses (HSV I and II, CMV, EBV, HPV6.11, HPV16 and HPV18) in the native oral mucosa of healthy volunteers (n=50; 30 men (60.0%), 20 women (40.0%); 25—74 years, median age — 55.0 years (95% CI 47.60-56.76)). All samples of the normal oral mucosa were detected by real-time PCR to detect viral DNA. The majority of the examined — 76% (33/50) — revealed the DNA: one type of viral DNA in 17 (38.00%) of the examined, a combination of the two types in 14 (28.00%). In the normal oral mucosa, DNA of Epstein-Barr virus was significantly more often detected: 15 (30.00%) (p = 0.0276) and human papilloma viruses 27 (54.00%) (p <0.0001), especially HPV-18 (24 (48.00%)): mono-association in 9 (18.00%) examined and in 7 (14.00%) in combination with EBV DNA (p = 0.0253). Keywords: oral mucosa, Epstein-Barr virus, human papilloma virus (type 6,11, 16, 18), herpes simplex virus (type I, II), cytomegalovirus.

For citation: Kutukova S.I., Chukhlovin A.B., Yaremenko A.I., Ivaskova Yu.V., Razumova A.Ya., Ermakova T.S. Association of normal oral mucosa with DNA of the main types of oncogenic viruses. Stomatology for All / Int. Dental Review. 2020, no.1(90): 60-63 (In Russian). doi: 10.35556/idr-2020-2(91)60-63

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