DOI: 10.35556/idr-2020-2(91)60-63

Association of normal oral mucosa with DNA of the main types of oncogenic viruses
Kutukova S.I.1, 2, Chukhlovin A.B.1, Yaremenko A.I.1, Ivaskova Yu.V.1, 2, Razumova A.Ya.1, Ermakova T.S.2
1 Pavlov First Saint Petersburg State Medical University, 197022, Russia, Saint Petersburg, L’va Tolstogo St., 6-8
2 City Clinical Oncology Center, Saint-Petersburg, 198255, Russia, Saint-Petersburg, Prospekt Veteranov, 56

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The aim of the study was to assess the prevalence of DNA viruses (HSV I and II, CMV, EBV, HPV6.11, HPV16 and HPV18) in the native oral mucosa of healthy volunteers (n=50; 30 men (60.0%), 20 women (40.0%); 25—74 years, median age — 55.0 years (95% CI 47.60-56.76)). All samples of the normal oral mucosa were detected by real-time PCR to detect viral DNA. The majority of the examined — 76% (33/50) — revealed the DNA: one type of viral DNA in 17 (38.00%) of the examined, a combination of the two types in 14 (28.00%). In the normal oral mucosa, DNA of Epstein-Barr virus was significantly more often detected: 15 (30.00%) (p = 0.0276) and human papilloma viruses 27 (54.00%) (p <0.0001), especially HPV-18 (24 (48.00%)): mono-association in 9 (18.00%) examined and in 7 (14.00%) in combination with EBV DNA (p = 0.0253). Keywords: oral mucosa, Epstein-Barr virus, human papilloma virus (type 6,11, 16, 18), herpes simplex virus (type I, II), cytomegalovirus.

For citation: Kutukova S.I., Chukhlovin A.B., Yaremenko A.I., Ivaskova Yu.V., Razumova A.Ya., Ermakova T.S. Association of normal oral mucosa with DNA of the main types of oncogenic viruses. Stomatology for All / Int. Dental Review. 2020, no.1(90): 60-63 (In Russian). doi: 10.35556/idr-2020-2(91)60-63


1. Bettendorf O., Piffko J., Bankfalvi A. Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy?. Oral Oncol. 2004, 40: 110—119.
2. Chen Y.K., Huang H.C., Lin L.M., Lin C.C. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncol. 1999, 35: 173.
3. Reichart P.A. Identification of risk groups for oral precancer and cancer and preventive measures. Clin Oral Investig. 2001, 5: 207—213.
4. Meurman J.H. Infectious and dietary risk factors of oral cancer. Oral Oncol. 2010, 46, 411—413.
5. Radochova V., Pliskova L., Slezak R. The prevalence of human papillomavirus in patient with oral lichen planus and normal mucosa. Acta virologica. 2015, 59: 434—436.
6. Liu T., Zhang H., Yang X. et al. Study on expression of p16 and human papillomavirus’16 and 18 (E6) in OLP and its malignant transformation. Pathology — Research and Practice. 2018, 214(2): 296—302.