Received 10.12.2024

DOI: 10.35556/idr-2025-1(110)20-23
Comparative analysis of disorders of the coagulation system and acid-base state (pH) of blood in patients with phlegmon of the maxillofacial region and neck
Kravets V.I. 1,2, ORCID: 0000-0002-6345-3993
Khelminskaya N.M. 1,2, ORCID: 0000-0002-3627-9109
Posadskaya A.V. 1,2, ORCID: 0000-0002-5926-8541
Eremin D.A. 1, ORCID: 0000-0003-4077-6359
Kravets A.V. 1, ORCID: 0000-0003-2744-5643
Vinokurova L.M. 1, ORCID: 0009-0005-6889-6979
1 Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation, Moscow
117997, Russia, Moscow, Ostrovityanova st., 1
² N.I.Pirogov Moscow City Clinical Hospital № 1
119049, Russia, Moscow, Leninsky Prospekt, 8

E-mail address: khelminskaya@mail.ru

Summary
The aim of the study was to conduct a comparative assessment of blood pH and basic parameters of coagulogram in patients with phlegmons of the maxillofacial region and neck.
In the course of the study, we retrospectively analyzed 100 case histories of patients aged 18 to 65 years who were hospitalized for phlegmon of the maxillofacial region and neck with the spread of purulent-inflammatory process to 4 and more cellular-fascial spaces.
The values of acid-base state of blood (pH) and standard coagulogram parameters (prothrombin, prothrombin time (PT), international normalized ratio (INR), fibrinogen) of venous blood taken from the peripheral vein in patients in the first hours of admission to the hospital were analyzed. According to the data obtained in the course of the study, the correlation of blood pH disorders in relation to changes in the parameters of the coagulation system approached zero or was weakly positive. The coagulogram and platelet count indirectly reflected the presence of a condition corresponding to sepsis-induced coagulopathy in patients.

Keywords: phlegmon of the maxillofacial area, sepsis-induced coagulopathy (SIC), blood рН, coagulogram.

For citation: Kravets V.I., Khelminskaya N.M., Posadskaya A.V., Eremin D.A., Kravets A.V., Vinokurova L.M. Comparative analysis of disorders of the coagulation system and acid-base state (pH) of blood in patients with phlegmon of the maxillofacial region and neck. Stomatology for All / Int. Dental Review. 2025; no. 1 (110): 20–23 (in Russian). doi: 10.35556/idr-2025-1(110)20-23

References

1. Mikheeva A.V., Afonchikov V.S., Volchkov V.A. Septic coagulopathy. Materials of the interregional scientific and practical conference with international participation “St. Petersburg Septic Forum–2018”. 2018; 117–118 (in Russian).
2. Sinkov S.V., Roitman E.V., Zabolotskikh I.B. New criteria for sepsis-induced coagulopathy. Bulletin of intensive care named after A.I. Saltanov. 2019; no. 3: 52–57 (in Russian). doi:10.21320/1818-474X-2019-3-52-57
3. Vasilitsyna A.A., Afonchikov V.S., Volchkov V.A. Determination of the functional activity of thrombocytes in sepsis using a modified thromboelastography technique. Anesthesiology and Reanimatology. 2019; no. 3: 56–61 (in Russian). doi: 10.17116/anaesthesiology201903156
4. Tsantes A.G., еt al. Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Life (Basel). 2023; no. 13 (2): 350. doi: 10.3390/life13020350
5. Alfonsova E.V., Kuznik B.I. The effect of metabolic acidosis on the structural organization of the endothelium. Fundamental research. 2014; no. 10 (8): 1451–1455 (in Russian).
6. Rajamaki K., еt al. Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome. J Biol Chem. 2013; no. 288 (19): 13410–13419. doi: 10.1074/jbc.M112.426254
7. Wilhelm G., Mertowska P., Mertowski S. et al. The Crossroads of the Coagulation System and the Immune System: Interactions and Connections. International Journal of Molecular. Sciences. 2023; no. 24 (16): 12563. doi: 10.3390/ijms241612563
8.Komlev V.L., Larichev A.B., Muravyev A.V. Severity of changes in hemorheological parameters in patients with acute purulent infection of soft tissues. Materials of the International Scientific and Practical Conference. Yaroslavl, 2020; 125–130 (in Russian).